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Normothermic Ex vivo Lung Perfusion: Toronto Protocol

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posted on 2021-08-11, 19:22 authored by Hemant Gokhale, Manyin Chen, Rafaela Ribeiro, Aizhou Wang, Marcelo Cypel, Jonathan Yeung, Shaf Keshavjee

The advent of normothermic ex vivo lung perfusion (EVLP) has allowed for significant increases in lung transplant volume, allowing for the recovery of lungs deemed unsuitable for transplantation. At our center, lung transplant activity has more than doubled within the last decade since the introduction of EVLP into our program. Here, we outline some of the important aspects of the Toronto EVLP protocol within a narrative video.


Cypel, M., Yeung, J. C., Hirayama, S., Rubacha, M., Fischer, S., Anraku, M., Sato, M., Harwood, S., Pierre, A., Waddell, T. K., de Perrot, M., Liu, M., & Keshavjee, S. (2008). Technique for prolonged normothermic ex vivo lung perfusion. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 27(12), 1319–1325. https://doi.org/10.1016/j.healun.2008.09.003

Cypel, M., Yeung, J. C., Liu, M., Anraku, M., Chen, F., Karolak, W., Sato, M., Laratta, J., Azad, S., Madonik, M., Chow, C. W., Chaparro, C., Hutcheon, M., Singer, L. G., Slutsky, A. S., Yasufuku, K., de Perrot, M., Pierre, A. F., Waddell, T. K., & Keshavjee, S. (2011). Normothermic ex vivo lung perfusion in clinical lung transplantation. The New England journal of medicine, 364(15), 1431–1440. https://doi.org/10.1056/NEJMoa1014597


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