<p>In this brief clinical video, the authors demonstrate the use of the Endo360⁰ suturing device from EndoEvolution (Assut Europe, SpA, Rome, Italy) for plication of the left hemidiaphragm. The authors believe that this is the first documented use of the Endo360⁰ for plication of the diaphragm.<br></p><p>The patient is a 66-year-old gentleman who underwent thyroidectomy for nonmalignant disease in 2014. He developed shortness of breath on exertion a few months after the procedure. He was evaluated and found to have iatrogenic left diaphragmatic paralysis. His performance status was 1, with FEV<sub>1</sub> 72%, FVC 104%, D<small>LCO</small> 90%, and KCO 119%. After obtaining the patient's informed consent and adequately preparing for the procedure, the patient was taken for elective video-assisted thoracoscopic (VATS) diaphragm plication. The video demonstrates the technique of using the Endo360⁰ in a three-port CO<sub>2</sub>-aided totally endoscopic VATS diaphragm plication.<br></p>